CARE Is a CDC Best Evidence Intervention


CDC “best evidence” for risk reduction, “good evidence” for medication adherence

The HIV/AIDS Prevention Research Synthesis (PRS) project at the U.S. Centers for Disease Control and Prevention (CDC) has designated CARE as a:

  • “Best evidence” intervention for risk reduction
  • “Good evidence” intervention for medication adherence

The designation is based on the results of the following study:

Kurth, A. E., Spielberg, F., Cleland, C. M., Lambdin, B., Bangsberg, D. R., Frick, P. A., . . . Holmes, K. K. (2014). Computerized counseling reduces HIV-1 viral load and sexual transmission risk: Findings from a randomized controlled trial. Journal of Acquired Immune Deficiency Syndromes, 65, 611-620. The report is available free from PubMed.

The PRS project identifies evidence-based interventions and best evidences to help HIV prevention planners and providers in the United States select interventions most appropriate for HIV prevention within their communities. CARE is one of the select interventions that qualifies for listing in the Compendium of Evidence-based HIV Behavioral Interventions (

The Risk Reduction (RR) Chapter of the Compendium highlights behavioral evidence-based interventions focusing on HIV-related risk reduction. CARE received a “best evidence” designation for risk reduction.

The Medication Adherence (MA) Chapter of the Compendium highlights evidence-based interventions that promote HIV medication adherence among persons living with HIV. CARE received a “good evidence” designation for medication adherence.


CARE-Pos is a ready-to-use tool for HIV treatment and risk reduction.

If you have special needs, we can customize CARE to your project or organization’s requirements.